Effective Drug Discovery
Label-Free high-throughput and resolution phenotypic screening and analysis of cellular assays
Job: Phenotypic Drug Discovery with High-Content Imaging
- PDD with image-based high-content screening/analysis (HCS/A) is a great way of identifying new drugs based on knowledge of distinct phenotypes.
- Cells and tissues are transparent: staining or fluorescent labeling increase cost/effort/time and may interfere with cellular function, skew the assays.
- Fluorescence imaging (preferred) is slower and more expensive than brightfield, especially at the high magnifications required for cellular analysis.
- Assays are much thicker than the depth of field: image multiple Z planes
Challenge: Label-Free High-Throughput+Resolution Screen
- High-resolution label-free microscopy of cells, closest to their natural state.
- Conventional DIC and phase-contrast are not quantitative and current quantitative phase microscopy (QPM) is limited in resolution and sensitivity (animal cells/tissues have very low index contrast features, <0.1).
- High-throughput high-resolution imaging of thick samples (cellular assays): current techniques are too slow or unreliable.
Label-Free High-Troughput and Resolution Phenotypic Screening and Analysis
Early-stage new drug development incurs 62% of total costs ($1.8B), while showing only 10% success rates. Better predictive biomarkers of pathology and drug response at the discovery stage will significantly increase success rates, lowering development time and cost.
Value Proposition
Coherent computational microscope for high-throughput screening of unstained/unlabeled cytology assays (cytomics) to capture perfectly focused cell images from the entire volume of the sample. The quantitative phase, amplitude and polarization data enables reliable automated classification of cellular phenotypes without interference from stains or fluorescent labels. Through quantitative normalization, data from different instruments/sites can be quantitatively corroborated.
Let’s Work Together
Microscopy technology has not evolved in its general practice for a century: it is still a labor intensive, difficult to scale, process.
Our technology is uniquely capable of fully-digital, high-accuracy, quantitative microscopy of stained and unstained samples.
Through synergistic collaboration, we can solve important health screening and diagnostic challenges, benefiting humanity.
Contact Us
We’re eager to learn about your requirements and happy to tell you more about our technology.
Ithaca, NY 14850
+1 917 436 1624
info@cdei.net